Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.93 |
| ▸ | TTPA | P49638 | 3/20 | 0.93 |
| ▸ | MAPT | P10636 | 2/20 | 0.93 |
| ▸ | MEN1 | O00255 | 2/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.93 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.93 |
| ▸ | USP2 | O75604 | 1/20 | 0.93 |
| ▸ | THRB | P10828 | 1/20 | 0.93 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.93 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.93 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.80 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.69 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | AKT1 | P31749 | 4/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Tocopherol SCHEMBL25189686 | 1.00 | LMNA (0.93) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL14167439 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL14297170 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tochopherol SCHEMBL22303 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL3059188 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL16451007 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tochopherol SCHEMBL14315133 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL17874901 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL20817063 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A | |
| SCHEMBL8084077 | 0.97 | LMNA (1.00) | LMNATTPAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015059129-A1 | SYNTHESIS OF CHROMANE COMPOUNDS AND THEIR DERIVATIVES BY A COPPER-CATALYZED CONJUGATE ADDITION REACTION | DSM IP ASSETS B.V. (NL) | 2015-04-30 | — | — | WO | disclosed |
| US-8426617-B2 | Asymmetric hydrogenation of alkenes using chiral iridium complexes | DSM IP ASSETS B.V. (NL) | 2013-04-23 | — | — | US | disclosed |
| EP-1828159-B1 | ASYMMETRIC HYDROGENATION OF ALKENES USING CHIRAL IRIDIUM COMPLEXES | DSM IP ASSETS BV (NL) | 2011-08-17 | — | — | EP | disclosed |
| US-20080039638-A1 | Asymmetric Hydrogenation of Alkennes Using Chiral Iridium Complexes | DSM IP ASSETS B.V. (NL) | 2008-02-14 | — | — | US | disclosed |
| EP-1828159-A1 | ASYMMETRIC HYDROGENATION OF ALKENES USING CHIRAL IRIDIUM COMPLEXES | DSMIP Assets B.V. (NL) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066863-A1 | ASYMMETRIC HYDROGENATION OF ALKENNES USING CHIRAL IRIDIUM COMPLEXES | DSM IP ASSETS B.V. (NL) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039638-A1 | Asymmetric Hydrogenation of Alkennes Using Chiral Iridium Complexes | SQLE, FADS1, FADS2 | LMNA 4536/4885TTPA 74/4885MAPT 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.