Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.55 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9340078 | 0.82 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL8559655 | 0.82 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL12030802 | 0.82 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL9118030 | 0.82 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL4049764 | 0.82 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL6839350 | 0.81 | KDM4E (0.46) | LMNACYP2C9ESR1NFKB1HTR2A | |
| SCHEMBL13690219 | 0.80 | LMNA (0.41) | LMNACYP2C9ESR1ADRB3NFKB1 | |
| SCHEMBL6055175 | 0.80 | TSHR (0.48) | LMNAAKR1C3ADRB3TSHRAKR1C2 | |
| SCHEMBL8794083 | 0.79 | PTGS1 (0.52) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL22125101 | 0.79 | TSHR (0.54) | PTGS1PTGS2CXCR1CXCR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312587-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2023-10-05 | — | — | US | disclosed |
| US-20230312587-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2023-10-05 | — | — | US | disclosed |
| US-11572364-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-02-07 | — | — | US | disclosed |
| US-11059826-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | PTGS1 518/4885PTGS2 1444/4885CXCR1 1867/4885 |
| US-11059826-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | PTGS1 518/4885PTGS2 1444/4885CXCR1 1867/4885 |
| US-20230312587-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | DPYD, PKD1, TYMP | PTGS1 518/4885PTGS2 1444/4885CXCR1 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.