Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.59 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 1/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049764 | 1.00 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL8559655 | 1.00 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL6436870 | 0.86 | ESR1 (0.48) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL12030802 | 0.86 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL9340078 | 0.86 | PTGS1 (0.59) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL23634205 | 0.82 | PTGS1 (0.55) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL13993311 | 0.82 | PTGS1 (0.55) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL28533038 | 0.82 | PTGS1 (0.55) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| Hydrogen Peroxide SCHEMBL9581174 | 0.82 | PTGS1 (0.64) | PTGS1PTGS2CXCR1CXCR2ALOX5 | |
| SCHEMBL1131597 | 0.82 | PTGS1 (0.56) | PTGS1PTGS2CXCR1CXCR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | SRI INTERNATIONAL (US) | 2023-05-02 | — | — | US | disclosed |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | SRI INTERNATIONAL (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | SRI INTERNATIONAL | 2021-04-22 | — | — | US | disclosed |
| EP-0398288-B1 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | PUETTER MEDICE CHEM PHARM (DE) | 1995-10-18 | — | — | EP | disclosed |
| US-5380927-A | Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-aryl-propionic acids | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0603278-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5266723-A | Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids | MEDICE, LTD., CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1993-11-30 | — | — | US | disclosed |
| WO-1993005019-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-18 | — | — | WO | disclosed |
| CN-1068816-A | indole derivatives | PFIZER (US) | 1993-02-10 | — | — | CN | disclosed |
| CN-1068817-A | INDOLE DERIVATIVES | PFIZER (US) | 1993-02-10 | — | — | CN | disclosed |
| WO-1993002051-A1 | INDOLES | PFIZER LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |
| WO-1993002050-A1 | INDOLES | PFIZER LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |
| EP-0398288-A2 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | PTGES2, PTGS2, PTGES | PTGS1 4/4885PTGS2 2/4885CXCR1 3077/4885 |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | PTGES2, PTGS2, PTGES | PTGS1 4/4885PTGS2 2/4885CXCR1 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.