Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11702238 | 0.79 | PGR (0.39) | ESR1NFKB1TSHR | |
| SCHEMBL23634205 | 0.79 | PTGS1 (0.55) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9118030 | 0.79 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8559655 | 0.79 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9340078 | 0.79 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL12030802 | 0.79 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL4049764 | 0.79 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL20215047 | 0.78 | ESR1 (0.54) | LMNAESR1HTR2ABLM | |
| SCHEMBL11834697 | 0.76 | PGR (0.42) | LMNACYP2C9ESR1NFKB1TSHR | |
| SCHEMBL13232164 | 0.76 | PGR (0.42) | PTGS1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993002050-A1 | INDOLES | PFIZER LIMITED (GB) | 1993-02-04 | — | — | WO | claimed |
| EP-0458207-B1 | Indole derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-26 | — | — | EP | disclosed |
| EP-0603278-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5312829-A | Testosterone 5alpha-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-17 | — | — | US | disclosed |
| US-5212320-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| WO-1993005019-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993002050-A1 | INDOLES | PFIZER LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |
| EP-0458207-A2 | Indole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-27 | — | — | EP | disclosed |