Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | LDLR | P01130 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23635154 | 0.86 | PIK3CA (0.39) | — | |
| SCHEMBL24187480 | 0.77 | RAB9A (0.51) | F10RAB9ALDLRPCSK9NPC1 | |
| SCHEMBL17027818 | 0.76 | F10 (0.54) | F10RAB9ADYRK1A | |
| SCHEMBL23635162 | 0.75 | DYRK1A (0.34) | RAB9ADYRK1ALDLRPCSK9HDAC3 | |
| SCHEMBL18979408 | 0.74 | HDAC2 (0.44) | F10RAB9ADYRK1ALDLRPCSK9 | |
| SCHEMBL17027749 | 0.73 | F10 (0.48) | F10RAB9ADYRK1A | |
| SCHEMBL23635155 | 0.73 | LDLR (0.38) | RAB9ADYRK1ALDLRPCSK9HDAC1 | |
| SCHEMBL18996612 | 0.67 | DYRK1A (0.48) | F10DYRK1A | |
| SCHEMBL17027809 | 0.66 | DYRK1A (0.42) | F10DYRK1A | |
| SCHEMBL18979456 | 0.65 | F10 (0.61) | F10DYRK1AHDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107909-B1 | ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS | FROST BIOLOGIC INC (US) | 2021-07-14 | — | — | EP | disclosed |