Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 2/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23635162 | 0.88 | DYRK1A (0.34) | LDLRPCSK9BRD4ABL1RIPK2 | |
| SCHEMBL17027858 | 0.78 | DYRK1A (0.47) | LDLRPCSK9ABL1KDRHDAC1 | |
| SCHEMBL18979428 | 0.76 | DYRK1A (0.41) | LDLRPCSK9BRD4ABL1SYK | |
| SCHEMBL23635153 | 0.73 | F10 (0.37) | LDLRPCSK9SRCHDAC1DYRK1A | |
| SCHEMBL23635154 | 0.70 | PIK3CA (0.39) | — | |
| SCHEMBL24187480 | 0.66 | RAB9A (0.51) | LDLRPCSK9NPC1RAB9A | |
| SCHEMBL18996612 | 0.66 | DYRK1A (0.48) | ABL1DYRK1AGSK3B | |
| SCHEMBL17027809 | 0.64 | DYRK1A (0.42) | ABL1DYRK1AGSK3B | |
| SCHEMBL28941910 | 0.63 | DYRK1A (0.49) | HDAC1DYRK1AGSK3B | |
| SCHEMBL17027818 | 0.63 | F10 (0.54) | DYRK1AGSK3BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107909-B1 | ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS | FROST BIOLOGIC INC (US) | 2021-07-14 | — | — | EP | disclosed |