Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | LDLR | P01130 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23635155 | 0.88 | LDLR (0.38) | DYRK1ALDLRPCSK9MAPK14BRD4 | |
| SCHEMBL18996612 | 0.78 | DYRK1A (0.48) | DYRK1AABL1GSK3B | |
| SCHEMBL17027809 | 0.76 | DYRK1A (0.42) | DYRK1AABL1GSK3B | |
| SCHEMBL23635153 | 0.75 | F10 (0.37) | DYRK1ALDLRPCSK9HDAC3HDAC1 | |
| SCHEMBL23635154 | 0.72 | PIK3CA (0.39) | — | |
| SCHEMBL23635137 | 0.71 | DYRK1A (0.39) | DYRK1AABL1GSK3B | |
| SCHEMBL23635161 | 0.69 | DYRK1A (0.44) | DYRK1AABL1GSK3B | |
| SCHEMBL24187480 | 0.66 | RAB9A (0.51) | LDLRPCSK9RAB9ANPC1L3MBTL1 | |
| SCHEMBL17027818 | 0.64 | F10 (0.54) | DYRK1ARAB9AGSK3B | |
| SCHEMBL17027858 | 0.64 | DYRK1A (0.47) | DYRK1ALDLRPCSK9HDAC1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107909-B1 | ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS | FROST BIOLOGIC INC (US) | 2021-07-14 | — | — | EP | disclosed |