Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | PLTP | P55058 | 4/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2316532 | 0.84 | RORC (0.49) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2485677 | 0.82 | PLTP (0.51) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2364172 | 0.82 | RORC (0.46) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL28792682 | 0.81 | ALDH1A1 (0.49) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2316445 | 0.80 | RORC (0.51) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2491127 | 0.80 | NPC1 (0.48) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2488862 | 0.80 | LMNA (0.56) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2320729 | 0.80 | PLTP (0.47) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2318105 | 0.79 | ALDH1A1 (0.49) | RORCPLTPDGAT1ADORA2AADORA1 | |
| SCHEMBL2484995 | 0.79 | PLTP (0.51) | RORCPLTPDGAT1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |