Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | VDR | P11473 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227948 | 0.77 | KIF11 (0.40) | KIF11VDRPOLBSMN1; SMN2LMNA | |
| SCHEMBL10110040 | 0.72 | MCL1 (0.39) | KIF11TDP1POLBSMN1; SMN2LMNA | |
| SCHEMBL10228100 | 0.72 | APP (0.47) | KIF11TDP1CYP2C9 | |
| SCHEMBL10227951 | 0.72 | ALDH1A1 (0.41) | KIF11VDRTDP1POLBSMN1; SMN2 | |
| SCHEMBL12260682 | 0.70 | ACHE (0.47) | KIF11TDP1SMN1; SMN2LMNA | |
| SCHEMBL6671026 | 0.69 | CES2 (0.40) | KIF11TDP1POLBSMN1; SMN2LMNA | |
| SCHEMBL10228098 | 0.69 | CNR2 (0.51) | VDRCACNA1BSMN1; SMN2LMNA | |
| SCHEMBL10228094 | 0.67 | NPC1 (0.38) | KIF11TDP1POLBSMN1; SMN2LMNA | |
| SCHEMBL1713303 | 0.66 | TDP1 (0.39) | KIF11VDRTDP1POLBSMN1; SMN2 | |
| SCHEMBL8736799 | 0.66 | TDP1 (0.39) | KIF11VDRTDP1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848361-A1 | METHOD OF PRODUCING TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2021-07-14 | — | — | EP | disclosed |