Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24302888 | 1.00 | MAPK14 (0.39) | MAPK14TDP1KMT2ACNR1KCNH2 | |
| SCHEMBL24303004 | 0.75 | MEN1 (0.41) | KMT2AKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL23640237 | 0.75 | MEN1 (0.41) | KMT2AKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL23640240 | 0.66 | SIGMAR1 (0.33) | — | |
| SCHEMBL1107035 | 0.64 | TDP1 (0.52) | TDP1KMT2AALDH1A1 | |
| SCHEMBL23640242 | 0.64 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL104788 | 0.64 | MAPK14 (0.56) | MAPK14KMT2AACACBMMP13ALDH1A1 | |
| SCHEMBL10099589 | 0.64 | HDAC3 (0.57) | MAPK14KMT2AKDM4EHDAC6HDAC3 | |
| SCHEMBL178383 | 0.64 | MMP13 (0.71) | MAPK14CNR1KCNH2CACNA1IMMP13 | |
| SCHEMBL2303341 | 0.62 | HDAC3 (0.64) | MAPK14KMT2AKDM4EHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |