Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | DDO | Q99489 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29678802 | 0.84 | ALDH1A1 (0.44) | CA9HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL15917911 | 0.82 | PTPN1 (0.46) | PTPN1CA9THRBHPGDMEN1 | |
| SCHEMBL31364598 | 0.81 | HPGD (0.59) | PTPN1CA9THRBHPGDMEN1 | |
| SCHEMBL23640511 | 0.79 | ERN1 (0.54) | PTPN1CA9THRBHPGDMEN1 | |
| SCHEMBL23640287 | 0.77 | CYP3A4 (0.56) | HPGDCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL426582 | 0.74 | ABCG2 (0.54) | CA9THRBHPGDALDH1A1MAPT | |
| SCHEMBL30574198 | 0.74 | ESR1 (0.58) | CA9MAOBDAOESR1ESR2 | |
| SCHEMBL30714893 | 0.74 | ABCG2 (0.54) | CA9THRBHPGDALDH1A1MAPT | |
| SCHEMBL6345593 | 0.74 | PTPN22 (0.50) | CA9THRBL3MBTL1MAPTLCK | |
| SCHEMBL5367030 | 0.74 | HSD17B1 (0.44) | CA9MEN1CYP3A4KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |