Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.54 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.40 |
| ▸ | GABRE | P78334 | 2/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157468 | 0.86 | MEN1 (0.45) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL6159010 | 0.86 | MEN1 (0.45) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL3259073 | 0.72 | GABRA1 (0.61) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL29391065 | 0.72 | GABRA1 (0.61) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11124045 | 0.72 | TSHR (0.40) | LMNACNR1PTPN1MEN1KMT2A | |
| SCHEMBL7544285 | 0.71 | CCKBR (0.43) | PTPN1CCKARCCKBRPDGFRAFER | |
| SCHEMBL7544295 | 0.71 | CCKBR (0.43) | PTPN1CCKARCCKBRPDGFRAFER | |
| SCHEMBL21272263 | 0.71 | CNR1 (0.55) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11882312 | 0.70 | CCKBR (0.50) | CCKARCCKBRMEN1KMT2A | |
| Ro-052921 SCHEMBL29979594 | 0.70 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139331-B1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | UNIV MICHIGAN (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-15 | — | — | US | disclosed |
| US-8242109-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-08-14 | — | — | US | disclosed |
| US-20110195959-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-08-11 | — | — | US | disclosed |
| US-7851465-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-14 | — | — | US | disclosed |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| US-7238685-B2 | Benzo-fused heterocycles as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-07-03 | — | — | US | disclosed |
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | ACTELION PHARMACEUTICALS LTD. | 2005-06-09 | — | — | US | disclosed |
| WO-2003013545-A1 | NOVEL BENZO-FUSED HETEROCYCLES AS ENDOTHELIN ANTAGONISITS | ACTELION PHARMACEUTICALS LTD (CH) | 2003-02-20 | — | — | WO | disclosed |
| WO-1996005178-A1 | SYNTHESIS OF BENZODIAZEPINES | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1996-02-22 | — | — | WO | disclosed |
| US-5466799-A | Triflating a 2,5-hydroxy benzophenone, cyclization with an ethylenediamine | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1995-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | EDNRA, EDNRB, ECE1 | GABRA1 41/4885GABRA5 38/4885GABRA3 65/4885 |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | GABRA1 36/4885GABRA5 20/4885GABRA3 33/4885 |
| US-20110195959-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | GABRA1 36/4885GABRA5 20/4885GABRA3 33/4885 |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | GABRA1 36/4885GABRA5 20/4885GABRA3 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.