Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157468 | 1.00 | MEN1 (0.45) | MEN1KMT2AATMGABRA1GABRG2 | |
| SCHEMBL2364518 | 0.86 | GABRA1 (0.54) | MEN1KMT2AATMGABRA1GABRG2 | |
| SCHEMBL29868676 | 0.76 | KDM4E (0.51) | MEN1KMT2AATMPTPN1ALDH1A1 | |
| SCHEMBL7759078 | 0.76 | KDM4E (0.51) | MEN1KMT2AATMPTPN1ALDH1A1 | |
| SCHEMBL27996594 | 0.75 | MEN1 (0.51) | MEN1KMT2AATMPTPN1ALDH1A1 | |
| SCHEMBL4764699 | 0.75 | MEN1 (0.51) | MEN1KMT2AATMPTPN1ALDH1A1 | |
| SCHEMBL11844524 | 0.73 | MEN1 (0.41) | MEN1KMT2AATMPTPN1MAOA | |
| SCHEMBL11844515 | 0.73 | MEN1 (0.41) | MEN1KMT2AATMPTPN1MAOA | |
| SCHEMBL27577140 | 0.71 | KDM4E (0.53) | MEN1KMT2AATMALDH1A1CES1 | |
| SCHEMBL7544285 | 0.69 | CCKBR (0.43) | MEN1KMT2APTPN1CCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044190-B1 | SYNTHESIS OF 11-ARYL-5,6-DIHYDRO-11H-DIBENZ(B,E)AZEPINES | JOHNSON MATTHEY PHARMACEUTICAL (US) | 2005-02-02 | — | — | EP | disclosed |