Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | PYGM | P11217 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364894 | 1.00 | DRD2 (0.44) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL7943270 | 0.89 | STAT6 (0.48) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL1929666 | 0.86 | PARP1 (0.45) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL2229048 | 0.84 | CYP51A1 (0.43) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL2229050 | 0.84 | CYP51A1 (0.43) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL6881854 | 0.83 | STAT6 (0.45) | DRD2SCN3ASCN4ASTAT6TAS1R3 | |
| SCHEMBL2229951 | 0.80 | CYP51A1 (0.39) | DRD2STAT6TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL7934440 | 0.79 | STAT6 (0.48) | DRD2STAT6CYP51A1HRH4CCKBR | |
| SCHEMBL14980442 | 0.79 | STAT6 (0.48) | DRD2STAT6CYP51A1HRH4CCKBR | |
| SCHEMBL7941749 | 0.79 | DRD2 (0.46) | DRD2STAT6TAS1R3TAS1R1CYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |