Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 4/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.36 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.36 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856859 | 0.88 | CYP51A1 (0.40) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL1549976 | 0.88 | CYP51A1 (0.40) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL1550050 | 0.88 | CYP51A1 (0.40) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL14980536 | 0.87 | HTR2B (0.46) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL6876269 | 0.86 | GHSR (0.44) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL14980460 | 0.85 | STAT6 (0.41) | CYP51A1DRD2HTR2BSTAT6CCKBR | |
| SCHEMBL1550049 | 0.84 | DRD2 (0.37) | CYP51A1DRD2HTR2BSTAT6HRH4 | |
| SCHEMBL12552765 | 0.83 | DRD2 (0.37) | CYP51A1DRD2STAT6KDM5AHSPA5 | |
| SCHEMBL1550195 | 0.83 | ALOX15 (0.42) | CYP51A1STAT6PYGL | |
| SCHEMBL1550758 | 0.83 | NAMPT (0.40) | CYP51A1DRD2STAT6HRH4KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | claimed |
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |