Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365270 | 0.84 | IRAK4 (0.38) | IRAK1IRAK4ENPP2MET | |
| SCHEMBL2362158 | 0.77 | IRAK1 (0.36) | IRAK1IRAK4 | |
| SCHEMBL2265280 | 0.75 | IRAK4 (0.36) | IRAK1IRAK4FGFR1FGFR2FGFR4 | |
| SCHEMBL2364224 | 0.70 | HCRTR1 (0.37) | — | |
| SCHEMBL2364584 | 0.69 | CHEK1 (0.33) | FGFR1FGFR2FGFR3KDR | |
| SCHEMBL2271726 | 0.67 | ENPP2 (0.34) | IRAK1IRAK4ENPP2 | |
| SCHEMBL13506534 | 0.67 | FGFR2 (0.37) | IRAK1IRAK4FGFR1FGFR2FGFR4 | |
| SCHEMBL2365492 | 0.67 | ROCK2 (0.36) | FGFR1KDRAURKAAURKBMET | |
| SCHEMBL2223764 | 0.66 | IRAK4 (0.36) | IRAK1IRAK4ENPP2IGF1RAURKA | |
| SCHEMBL371056 | 0.64 | PDE10A (0.41) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |