Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364224 | 0.75 | HCRTR1 (0.37) | — | |
| SCHEMBL2365270 | 0.73 | IRAK4 (0.38) | FYN | |
| SCHEMBL2221788 | 0.72 | MET (0.34) | CYP4F2CYP4A11FGFR3KDRBRD4 | |
| SCHEMBL2365324 | 0.69 | IRAK1 (0.34) | FGFR3KDRFGFR1FGFR2 | |
| SCHEMBL22309842 | 0.69 | S1PR1 (0.52) | CHEK1CHEK2FGFR3KDRFYN | |
| SCHEMBL2362158 | 0.67 | IRAK1 (0.36) | — | |
| SCHEMBL24081446 | 0.66 | RXRA (0.38) | FGFR3KDRBRD4FGFR1FGFR2 | |
| SCHEMBL2222925 | 0.66 | FYN (0.53) | FGFR3KDRFYNCNR1CNR2 | |
| SCHEMBL2220774 | 0.63 | ENPP2 (0.34) | FGFR3KDRBRD4CCL2FGFR2 | |
| SCHEMBL2271552 | 0.63 | HSD17B13 (0.38) | CHEK1CHEK2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |