Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313163 | 0.86 | TSHR (0.38) | LMNASMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL1368631 | 0.85 | AKR1C3 (0.39) | LMNAHRH4AKR1C3AKR1C2G6PD | |
| SCHEMBL26812067 | 0.82 | LMNA (0.43) | LMNAHRH4AKR1C3AKR1C2G6PD | |
| SCHEMBL15077045 | 0.78 | HTT (0.51) | LMNAHRH4AKR1C3AKR1C2G6PD | |
| SCHEMBL17914482 | 0.77 | PSEN1 (0.45) | LMNAHRH4AKR1C3AKR1C2PTGS2 | |
| SCHEMBL12695017 | 0.74 | ALDH1A1 (0.47) | LMNAAKR1C3AKR1C2G6PDIDE | |
| SCHEMBL20780320 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2PTGS2ALDH1A1TSHR | |
| SCHEMBL24574571 | 0.74 | LMNA (0.42) | LMNAG6PDIDESMN1; SMN2ENPP2 | |
| SCHEMBL1369917 | 0.73 | G6PD (0.50) | HRH4AKR1C3AKR1C2G6PDIDE | |
| SCHEMBL10105627 | 0.73 | PTGS2 (0.43) | AKR1C3AKR1C2G6PDIDESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022135591-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDONE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-06-30 | — | — | WO | disclosed |
| WO-2021249563-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2021-12-16 | — | — | WO | disclosed |
| WO-2021143693-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2021-07-22 | — | — | WO | disclosed |