Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.45 |
| ▸ | PGR | P06401 | 12/20 | 0.45 |
| ▸ | AR | P10275 | 8/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23664954 | 1.00 | NR3C1 (0.45) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL20200808 | 1.00 | NR3C1 (0.45) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL10939796 | 0.95 | NR3C1 (0.43) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL14656657 | 0.91 | NR3C1 (0.36) | NR3C1PGRARNR3C2 | |
| SCHEMBL14666279 | 0.91 | NR3C1 (0.36) | NR3C1PGRARNR3C2 | |
| SCHEMBL14656695 | 0.90 | NR3C1 (0.36) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL14666121 | 0.90 | NR3C1 (0.36) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL14666125 | 0.89 | AR (0.35) | NR3C1PGRARNR3C2MEN1 | |
| SCHEMBL14656738 | 0.89 | AR (0.35) | NR3C1PGRARNR3C2MEN1 | |
| SCHEMBL14666100 | 0.89 | NR3C1 (0.34) | NR3C1PGRARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221838-A1 | METHODS FOR ONAPRISTONE SYNTHESIS DEHYDRATION AND DEPROTECTION | ARNO THERAPEUTICS, INC. | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221838-A1 | METHODS FOR ONAPRISTONE SYNTHESIS DEHYDRATION AND DEPROTECTION | ADH1A, ADH1C, ADH5 | NR3C1 240/4885PGR 1629/4885AR 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.