Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SDCBP | O00560 | 3/20 | 0.41 |
| ▸ | SDC2 | P34741 | 3/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23896949 | 0.88 | ALOX15 (0.42) | KCNH2ALOX15MAPTSMN1; SMN2SDCBP | |
| SCHEMBL26711790 | 0.82 | GABRA1 (0.36) | KCNH2SDCBPSDC2PRMT5WDR77 | |
| SCHEMBL23639832 | 0.82 | PRMT5 (0.39) | ALOX15MAPTSMN1; SMN2SDCBPSDC2 | |
| SCHEMBL17517148 | 0.81 | KCNH2 (0.40) | KCNH2ALOX15MAPTSMN1; SMN2PRF1 | |
| SCHEMBL12870532 | 0.81 | PRMT5 (0.45) | MAPTSDCBPSDC2PRMT5WDR77 | |
| SCHEMBL26711841 | 0.81 | PRMT5 (0.43) | MAPTSDCBPSDC2PRF1PRMT5 | |
| SCHEMBL20132959 | 0.78 | VHL (0.43) | KCNH2ALOX15MAPTSMN1; SMN2PRF1 | |
| SCHEMBL14216458 | 0.78 | KCNH2 (0.46) | KCNH2SDCBPSDC2PRF1GRM5 | |
| SCHEMBL20132873 | 0.77 | KCNH2 (0.41) | KCNH2ALOX15MAPTSMN1; SMN2SDCBP | |
| SCHEMBL20330142 | 0.76 | SDCBP (0.57) | KCNH2SDCBPSDC2PRF1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023240038-A1 | TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023215471-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |
| US-20210221796-A1 | ANTIBACTERIAL COMPOUNDS | BLACKSMITH MEDICINES, INC. | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221796-A1 | ANTIBACTERIAL COMPOUNDS | SPOUT1, MRPL21, NRDC | KCNH2 4251/4885ALOX15 2019/4885MAPT 2641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.