Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367025 | 0.85 | CYP3A4 (0.47) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL2367386 | 0.84 | CYP3A4 (0.46) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL9978632 | 0.80 | HTT (0.43) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL2367303 | 0.79 | CYP1A2 (0.68) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL23794996 | 0.77 | SLC6A4 (0.41) | CYP1A2CYP2C19MEN1KMT2ACYP2D6 | |
| SCHEMBL16335384 | 0.77 | SLC6A4 (0.41) | CYP1A2CYP2C19MEN1KMT2ACYP2D6 | |
| SCHEMBL9729609 | 0.77 | IDO1 (0.47) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL2366778 | 0.77 | SLC6A4 (0.41) | CYP1A2CYP2C19MEN1KMT2ACYP2D6 | |
| SCHEMBL2659771 | 0.76 | IDO1 (0.54) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL2367062 | 0.75 | SLC6A4 (0.64) | CYP1A2MEN1KMT2ACYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013801-B1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2018-08-22 | — | — | EP | disclosed |
| US-9637457-B2 | Process for the stereoselective preparation of a pyrazole-carboxamide | SYNGENTA PARTICIPATIONS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| EP-3013801-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | Syngenta Participations AG (CH) | 2016-05-04 | — | — | EP | disclosed |
| US-20160108001-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | US | disclosed |
| WO-2014206855-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2014-12-31 | — | — | WO | disclosed |
| EP-2364293-B1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2364293-B1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8258169-B2 | Pyrazole-4-N-alkoxycarboxamides as microbiocides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-22 | — | — | US | disclosed |
| EP-2364293-A2 | NOVEL MICROBIOCIDES | Syngenta Participations AG (CH) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010063700-A2 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010063700-A2 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230537-A1 | NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES | CASP1, CASP14, CD14 | CYP1A2 202/4885CYP3A4 92/4885CYP2C19 113/4885 |
| US-20160108001-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | CYP3A4, CYP2C9, CYP2C19 | CYP1A2 25/4885CYP3A4 1/4885CYP2C19 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.