Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686165 | 0.79 | MAOB (0.52) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL21137793 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL2498833 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4024136 | 0.78 | LMNA (0.52) | NPC1RAB9AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3258201 | 0.78 | LMNA (0.52) | NPC1RAB9AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL12593473 | 0.78 | LMNA (0.52) | NPC1RAB9AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL862550 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AGRIN2DGRIN3B | |
| SCHEMBL21527117 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AGRIN2DGRIN3B | |
| SCHEMBL2152564 | 0.76 | GRIN2D (0.50) | SMN1; SMN2NPC1RAB9AGRIN2DGRIN3B | |
| SCHEMBL29525159 | 0.74 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9ACYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230149-A1 | ARYLNAPHTHALENE COMPOUNDS AS VACUOLAR-ATPASE INHIBITORS AND THE USE THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230149-A1 | ARYLNAPHTHALENE COMPOUNDS AS VACUOLAR-ATPASE INHIBITORS AND THE USE THEREOF | VCP, ATP6V1H, NSF | SMN1; SMN2 1540/4885NPC1 65/4885RAB9A 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.