Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368956 | 0.84 | HTT (0.55) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2369522 | 0.81 | MAPT (0.38) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL5790076 | 0.81 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2368757 | 0.78 | LMNA (0.47) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL5791585 | 0.76 | MAPT (0.51) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2368766 | 0.74 | MITF (0.44) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL5803878 | 0.74 | HTT (0.47) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2368559 | 0.72 | CHEK1 (0.43) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2369951 | 0.70 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL6663533 | 0.69 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTLMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |