Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368684 | 0.80 | HTT (0.58) | MAPTSMN1; SMN2HTTKMT2AKDM4E | |
| SCHEMBL5376619 | 0.77 | MAPT (0.53) | MAPTHTTKMT2ALMNAALDH1A1 | |
| SCHEMBL30700550 | 0.76 | DHFR (0.41) | MAPTSMN1; SMN2HTTKMT2ACLK1 | |
| SCHEMBL2369951 | 0.75 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2HTTKMT2ACLK1 | |
| SCHEMBL2368915 | 0.70 | SMN1; SMN2 (0.38) | MAPTSMN1; SMN2HTTKMT2ACYP17A1 | |
| SCHEMBL14964882 | 0.69 | FGFR1 (0.53) | MAPTSMN1; SMN2HTTCYP17A1KDM4E | |
| SCHEMBL28432909 | 0.68 | AHR (0.45) | MAPTSMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL29624840 | 0.67 | AHR (0.64) | MAPTKDM4EMGAMALDH1A1GAA | |
| SCHEMBL464507 | 0.67 | AHR (0.64) | MAPTKDM4EMGAMALDH1A1GAA | |
| SCHEMBL2368808 | 0.67 | LMNA (0.55) | MAPTSMN1; SMN2HTTKMT2ACYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |