Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368808 | 0.83 | LMNA (0.55) | HTTMAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL14964882 | 0.83 | FGFR1 (0.53) | HTTMAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL30700550 | 0.83 | DHFR (0.41) | HTTMAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL2369460 | 0.80 | MAPT (0.40) | HTTMAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL2368931 | 0.80 | DGAT1 (0.55) | HTTMAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL2368915 | 0.80 | SMN1; SMN2 (0.38) | HTTMAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL5376619 | 0.78 | MAPT (0.53) | HTTMAPTKMT2ALMNAFGFR1 | |
| SCHEMBL2367997 | 0.76 | LMNA (0.49) | MAPTSMN1; SMN2KMT2ALMNAFGFR1 | |
| SCHEMBL2369304 | 0.74 | CYP2A6 (0.51) | MAPTNPSR1 | |
| SCHEMBL2368945 | 0.74 | MAPT (0.53) | HTTMAPTSMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |