Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.50 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289115 | 0.84 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2ALTA4H | |
| SCHEMBL560292 | 0.77 | ALDH1A1 (0.48) | HPGDALDH1A1MEN1KMT2AHTT | |
| SCHEMBL30064859 | 0.77 | ALDH1A1 (0.48) | HPGDALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2580611 | 0.74 | KEAP1 (0.59) | SMN1; SMN2KDM4ESLC5A2SLC5A1MAPT | |
| SCHEMBL3622807 | 0.74 | MEN1 (0.66) | SMN1; SMN2KDM4EHPGDSLC5A2SLC5A1 | |
| SCHEMBL4293026 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EHPGDSLC5A2SLC5A1 | |
| SCHEMBL2488793 | 0.72 | NQO1 (0.74) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL3329675 | 0.71 | L3MBTL1 (0.49) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL12135093 | 0.71 | LTA4H (0.70) | SMN1; SMN2MAPTALDH1A1NQO1LTA4H | |
| SCHEMBL2136831 | 0.70 | TSHR (0.50) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542236-A1 | 6 -BENZYLPHENYL- 2 - SULFURTERAHYDROPYRAN-3, 4, 5 -TRIOL DERIVATIVES AS INHIBITORS OF SODIUM -GLUCOSE COTRANS PORTERS 1 AND 2 FOR USE IN DIABETIC PATIENTS | Lexicon Pharmaceuticals, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109333-A1 | 6 -BENZYLPHENYL- 2 - SULFURTERAHYDROPYRAN-3, 4, 5 -TRIOL DERIVATIVES AS INHIBITORS OF SODIUM -GLUCOSE COTRANS PORTERS 1 AND 2 FOR USE IN DIABETIC PATIENTS | LEXICON PHARMACEUTICALS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |