Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887104 | 1.00 | MAPT (0.67) | MAPTRAB9ANPC1KDM4EPKM | |
| SCHEMBL23698296 | 0.85 | MAPT (0.67) | MAPTRAB9ANPC1KDM4EPKM | |
| SCHEMBL23698297 | 0.85 | MAPT (0.67) | MAPTRAB9ANPC1KDM4EPKM | |
| SCHEMBL8291982 | 0.81 | MAPT (0.66) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23698299 | 0.80 | ALDH1A1 (0.60) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL23698298 | 0.80 | ALDH1A1 (0.60) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL23230120 | 0.79 | MAPT (0.64) | MAPTRAB9ANPC1KDM4EPKM | |
| SCHEMBL28520366 | 0.78 | DNM1 (0.61) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL21887094 | 0.77 | DNM1 (0.72) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL30714864 | 0.77 | MAPT (0.61) | MAPTRAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | disclosed |