Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841998 | 0.83 | TSHR (0.58) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL4727160 | 0.81 | HTT (0.57) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL14529331 | 0.80 | HTT (0.52) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL4970093 | 0.76 | HTT (0.49) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL28303262 | 0.76 | HTT (0.49) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL217862 | 0.74 | TP53 (0.69) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL4728733 | 0.73 | TP53 (0.63) | TSHRHTTFABP4TP53LMNA | |
| Ammonia Solution, Strong SCHEMBL28097128 | 0.72 | TP53 (0.67) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL10801457 | 0.72 | SMN1; SMN2 (0.65) | TSHRHTTFABP4TP53LMNA | |
| SCHEMBL27855435 | 0.71 | TSHR (0.46) | TSHRHTTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856742-A1 | TRICYCLIC JANUS KINASE 1 INHIBITORS, AND COMPOSITIONS AND METHODS THEREOF | Lynk Pharmaceuticals Co. Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |