Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877544 | 0.80 | PDPK1 (0.38) | PIN1PDPK1MAOAMAOB | |
| SCHEMBL12924867 | 0.79 | SLC6A3 (0.51) | TSHRKMT2AALDH1A1LMNA | |
| SCHEMBL23699443 | 0.77 | USP2 (0.43) | TSHRPIN1USP2PDE4APDE4B | |
| SCHEMBL23934503 | 0.76 | USP2 (0.45) | TSHRPIN1USP2PDE4APDE4B | |
| SCHEMBL7407546 | 0.74 | IDO1 (0.40) | PIN1PDPK1MAOAMAOB | |
| SCHEMBL28750554 | 0.74 | TSHR (0.43) | TSHRPIN1USP2PDE4APDE4B | |
| SCHEMBL8809100 | 0.73 | TSHR (0.53) | TSHRUSP2MEN1KMT2AALDH1A1 | |
| SCHEMBL11733442 | 0.73 | PPARG (0.45) | TSHRPIN1PDPK1MEN1KMT2A | |
| SCHEMBL8522139 | 0.72 | IDO1 (0.44) | PDPK1MAOAMAOB | |
| SCHEMBL8166235 | 0.71 | PPARG (0.46) | TSHRPIN1ALDH1A1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858439-A1 | AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2021-08-04 | — | — | EP | disclosed |