Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 5/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27583416 | 0.89 | ALDH1A1 (0.39) | TSHRUSP2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27649366 | 0.86 | ECE1 (0.41) | ALDH1A1ECE1 | |
| SCHEMBL23699443 | 0.75 | USP2 (0.43) | TSHRUSP2PDE4APDE4BPDE4C | |
| SCHEMBL12924867 | 0.75 | SLC6A3 (0.51) | TSHRKMT2AALDH1A1 | |
| SCHEMBL23699381 | 0.74 | TSHR (0.44) | TSHRUSP2PDE4APDE4BPDE4C | |
| SCHEMBL23934503 | 0.72 | USP2 (0.45) | TSHRUSP2PDE4APDE4BPDE4C | |
| SCHEMBL17335654 | 0.71 | TRPM8 (0.44) | PIN1IDO1PDPK1 | |
| SCHEMBL15882481 | 0.71 | TRPM8 (0.44) | PIN1IDO1PDPK1 | |
| SCHEMBL31757665 | 0.71 | DRD2 (0.41) | IDO1MAPTALDH1A1 | |
| SCHEMBL31758027 | 0.71 | DRD2 (0.41) | IDO1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1396906-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2003-02-12 | — | — | CN | disclosed |