SCHEMBL23701729

SCHEMBL23701729

O=C(O)Cc1c[nH]c2ccc(-c3ccc(F)c(Cl)c3)cc12

nearest known ligand 0.80

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ICMT O60725 9/20 0.80
TSHR P16473 2/20 0.63
ALDH1A1 P00352 1/20 0.57
LMNA P02545 1/20 0.57
GLA P06280 1/20 0.57
CYP2C9 P11712 1/20 0.57
HPGD P15428 1/20 0.57
NFKB1 P19838 1/20 0.57
PMP22 Q01453 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
KDM4E B2RXH2 1/20 0.52
NR4A1 P22736 1/20 0.45
ERCC1 P07992 1/20 0.45
ERCC4 Q92889 1/20 0.45
GPR84 Q9NQS5 2/20 0.43
CNR2 P34972 1/20 0.43
RPA1 P27694 1/20 0.42
HTR2A P28223 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6509009 0.87 TSHR (0.62) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL23701771 0.85 TSHR (0.63) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL29486513 0.83 TSHR (0.58) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL24612560 0.83 TSHR (0.58) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL23701766 0.81 TSHR (0.56) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL23701757 0.81 TSHR (0.66) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL30261856 0.81 TSHR (0.66) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL1615011 0.81 TSHR (0.69) TSHRALDH1A1LMNAGLACYP2C9
SCHEMBL2260803 0.78 TSHR (1.00) ICMTTSHRALDH1A1LMNAGLA
SCHEMBL23701735 0.77 TSHR (0.61) ICMTTSHRALDH1A1LMNAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12150447-B2 Plant growth regulator UNIVERSITY OF WASHINGTON (US) 2024-11-26 US disclosed
US-20210235697-A1 PLANT GROWTH REGULATOR UNIVERSITY OF WASHINGTON (US) 2021-08-05 US disclosed
US-20210235697-A1 PLANT GROWTH REGULATOR UNIVERSITY OF WASHINGTON (US) 2021-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210235697-A1 PLANT GROWTH REGULATOR ING2, GHRHR, MYB ICMT 1658/4885TSHR 57/4885ALDH1A1 3460/4885
US-12150447-B2 Plant growth regulator ING2, GHRHR, MYB ICMT 1658/4885TSHR 57/4885ALDH1A1 3460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.