Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ordopidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ordopidine SCHEMBL30522152 | 1.00 | DRD3 (0.46) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| Ordopidine SCHEMBL2370600 | 0.99 | DRD3 (0.47) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| SCHEMBL13304588 | 0.94 | DRD3 (0.44) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| SCHEMBL2783233 | 0.88 | DRD2 (0.55) | DRD3HTR6DRD2SIGMAR1SLC6A4 | |
| SCHEMBL13815538 | 0.86 | SIGMAR1 (0.47) | DRD3HTR6DRD2SIGMAR1SLC6A4 | |
| Ordopidine SCHEMBL5506147 | 0.85 | HTR6 (0.38) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| SCHEMBL2783693 | 0.85 | KDM4E (0.38) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| SCHEMBL2784849 | 0.85 | DRD3 (0.45) | DRD3HTR6HRH3DRD2SIGMAR1 | |
| SCHEMBL2783821 | 0.85 | DRD3 (0.45) | DRD3HTR6HRH3DRD2SLC6A4 | |
| SCHEMBL2781820 | 0.84 | HTR6 (0.48) | DRD3HTR6HRH3DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011107583-A1 | SUBSTITUTED 4-PHENYL-N-ALKYL-PIPERIDINES FOR PREVENTING ONSET OR SLOWING PROGRESSION OF NEURODEGENERATIVE DISORDERS | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-09-09 | — | — | WO | claimed |
| WO-2011107583-A1 | SUBSTITUTED 4-PHENYL-N-ALKYL-PIPERIDINES FOR PREVENTING ONSET OR SLOWING PROGRESSION OF NEURODEGENERATIVE DISORDERS | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-09-09 | — | — | WO | disclosed |