Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ordopidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782438 | 0.89 | DRD3 (0.45) | HTR6DRD3HRH3DRD2MEN1 | |
| SCHEMBL5506150 | 0.87 | HTR6 (0.34) | HTR6DRD3HRH3DRD2MEN1 | |
| SCHEMBL2784642 | 0.86 | DRD3 (0.46) | HTR6DRD3HRH3DRD2MEN1 | |
| Ordopidine SCHEMBL2370600 | 0.86 | DRD3 (0.47) | HTR6DRD3HRH3DRD2SIGMAR1 | |
| Ordopidine SCHEMBL30522152 | 0.85 | DRD3 (0.46) | HTR6DRD3HRH3DRD2SIGMAR1 | |
| Ordopidine SCHEMBL2370525 | 0.85 | DRD3 (0.46) | HTR6DRD3HRH3DRD2SIGMAR1 | |
| SCHEMBL13304588 | 0.82 | DRD3 (0.44) | HTR6DRD3HRH3DRD2SIGMAR1 | |
| SCHEMBL5502367 | 0.82 | DRD2 (0.45) | HTR6DRD3HRH3DRD2MEN1 | |
| SCHEMBL2782207 | 0.81 | DRD3 (0.47) | HTR6DRD3HRH3DRD2KMT2A | |
| SCHEMBL2782202 | 0.81 | DRD2 (0.56) | HTR6DRD3DRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |