Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 5/20 | 0.50 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | PMM2 | O15305 | 1/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18020094 | 0.86 | MAPK1 (0.68) | MAPK1GSK3AGSK3BL3MBTL1KDM4E | |
| SCHEMBL881155 | 0.84 | L3MBTL1 (0.57) | MAPK1L3MBTL1KDM4EATMPGR | |
| SCHEMBL12251851 | 0.83 | ALDH1A1 (0.50) | MAPK1ATMGAAMEN1ALDH1A1 | |
| SCHEMBL1722780 | 0.80 | GSK3B (0.71) | MAPK1GSK3AGSK3BL3MBTL1KDM4E | |
| SCHEMBL14933357 | 0.74 | MAPK1 (0.61) | MAPK1L3MBTL1KDM4EATMPGR | |
| SCHEMBL6362698 | 0.73 | GSK3A (0.56) | MAPK1GSK3AGSK3BL3MBTL1KDM4E | |
| SCHEMBL17108164 | 0.73 | MAPK1 (0.55) | MAPK1GSK3AGSK3BL3MBTL1KDM4E | |
| SCHEMBL30286748 | 0.73 | L3MBTL1 (0.74) | MAPK1L3MBTL1KDM4EATMPGR | |
| SCHEMBL127119 | 0.73 | L3MBTL1 (0.74) | MAPK1L3MBTL1KDM4EATMPGR | |
| SCHEMBL6362495 | 0.72 | PGR (0.71) | MAPK1GSK3AGSK3BL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230139809-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | US | disclosed |
| US-20230139809-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | US | disclosed |
| WO-2021151922-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230139809-A1 | BENZIMIDAZOLE DERIVATIVES | ECI1, COX4I1, BRD4 | MAPK1 3850/4885GSK3A 3260/4885GSK3B 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.