Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21345494 | 0.89 | CHRM2 (0.43) | EPHX2EPHX1JAK1JAK3OPRL1 | |
| SCHEMBL24171104 | 0.83 | EPHX2 (0.41) | MEN1KMT2AEPHX2EPHX1OPRL1 | |
| SCHEMBL23710176 | 0.82 | FAAH (0.49) | SIGMAR1MEN1KMT2AEPHX2GPR119 | |
| SCHEMBL3956739 | 0.82 | MEN1 (0.42) | MEN1KMT2AEPHX2EPHX1OPRL1 | |
| SCHEMBL3956738 | 0.82 | MEN1 (0.39) | SIGMAR1MEN1KMT2AEPHX2EPHX1 | |
| SCHEMBL12561511 | 0.80 | POLB (0.51) | MEN1KMT2AEPHX2EPHX1ITGB3 | |
| SCHEMBL7299175 | 0.80 | AKR1C3 (0.45) | EPHX2EPHX1ITGB3ITGA2BGNAI3 | |
| SCHEMBL6705700 | 0.80 | GPR119 (0.54) | GPR119 | |
| SCHEMBL7226796 | 0.79 | EPHX2 (0.40) | EPHX2EPHX1ITGB3ITGA2BGNAI3 | |
| SCHEMBL26263461 | 0.79 | GNAI3 (0.53) | SIGMAR1EPHX2EPHX1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |