Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27270190 | 0.90 | FAAH (0.45) | FAAHSIGMAR1EPHX2L3MBTL1CHRM2 | |
| SCHEMBL23710202 | 0.88 | FAAH (0.47) | FAAHEPHX2L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL23710138 | 0.85 | FAAH (0.47) | FAAHEPHX2L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL23710149 | 0.82 | SIGMAR1 (0.44) | SIGMAR1EPHX2MEN1KMT2AITGB3 | |
| SCHEMBL26224205 | 0.82 | FAAH (0.52) | FAAHCHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL23560471 | 0.81 | FAAH (0.51) | FAAHMEN1ALDH1A1KMT2AITGB3 | |
| SCHEMBL25888045 | 0.80 | FAAH (0.41) | FAAHEPHX2L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL25075013 | 0.79 | FAAH (0.50) | FAAHEPHX2L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL23695831 | 0.79 | FAAH (0.50) | FAAHEPHX2L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL25915855 | 0.79 | GNAI3 (0.51) | FAAHMEN1KMT2AITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |