Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.53 |
| ▸ | METAP1 | P53582 | 6/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984962 | 0.91 | METAP2 (0.55) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19309026 | 0.89 | METAP2 (0.53) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL12022117 | 0.89 | METAP2 (0.53) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7356908 | 0.86 | METAP2 (0.70) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7355712 | 0.85 | METAP2 (0.69) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5534127 | 0.80 | CHRNB2 (0.50) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5518458 | 0.75 | CTSS (0.53) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14984958 | 0.73 | METAP2 (0.76) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL12022088 | 0.72 | METAP2 (0.74) | METAP2METAP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL21017020 | 0.72 | METAP2 (0.74) | METAP2METAP1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858385-A2 | POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF | Syndevrx, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |