Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12038632 | 0.88 | CTSD (0.51) | CTSDCTSLCTSSCA1CA2 | |
| SCHEMBL12022069 | 0.82 | CTSD (0.51) | CTSDALDH1A1CTSLCTSSCA1 | |
| SCHEMBL7359549 | 0.81 | METAP2 (0.57) | CTSDMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7356534 | 0.80 | METAP2 (0.56) | CTSDMETAP2METAP1 | |
| SCHEMBL21582888 | 0.78 | MMP3 (0.45) | CTSDCTSLCTSSMETAP2METAP1 | |
| SCHEMBL17880861 | 0.77 | METAP2 (0.44) | CTSLCTSSMETAP2METAP1 | |
| SCHEMBL14984963 | 0.77 | METAP2 (0.44) | CTSLCTSSMETAP2METAP1 | |
| SCHEMBL18596854 | 0.75 | PKM (0.40) | CTSDLMNAPKMMETAP2METAP1 | |
| SCHEMBL14984991 | 0.73 | NPC1 (0.53) | ALDH1A1LMNAHTTMETAP2METAP1 | |
| SCHEMBL11475368 | 0.73 | EPHX2 (0.67) | ALDH1A1CA1CA2CNR1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858385-A2 | POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF | Syndevrx, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |