Cifenline

Cifenline

SCHEMBL23712302

c1ccc(C2(c3ccccc3)C[C@H]2C2=NCCN2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 1/20 1.00
AR P10275 1/20 1.00
PDE4A P27815 1/20 1.00
SCN1A P35498 1/20 1.00
SCN4A P35499 1/20 1.00
SCN7A Q01118 1/20 1.00
CACNA1D Q01668 1/20 1.00
KCNH2 Q12809 1/20 1.00
CACNA1S Q13698 1/20 1.00
CACNA1C Q13936 1/20 1.00
SCN5A Q14524 1/20 1.00
SCN9A Q15858 1/20 1.00
SCN2A Q99250 1/20 1.00
SCN3A Q9NY46 1/20 1.00
SCN11A Q9UI33 1/20 1.00
SCN8A Q9UQD0 1/20 1.00
SCN10A Q9Y5Y9 1/20 1.00
ADRA2A P08913 8/20 0.49
ADRA2B P18089 3/20 0.49
ADRA2C P18825 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cifenline SCHEMBL122806 1.00 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL23712274 1.00 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL121044 0.89 CACNA1F (0.79) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL29387230 0.89 CACNA1F (0.79) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL28086532 0.74 CACNA1F (0.55) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL5998298 0.68 KDM1A (0.57) CACNA1FARPDE4ASCN1ASCN4A
Biphenyl SCHEMBL27968805 0.67 NISCH (0.58) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL23712311 0.67 CACNA1F (0.50) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL17886752 0.66 NISCH (1.00) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL17886835 0.66 NISCH (1.00) CACNA1FARPDE4ASCN1ASCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3858816-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE Celltrion, Inc. (KR) 2021-08-04 EP disclosed