Cifenline

Cifenline

SCHEMBL29387230

O=C(O)/C=C/C(=O)O.c1ccc(C2(c3ccccc3)CC2C2=NCCN2)cc1

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Cifenline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 known ✓ Q12809 1/20 0.79
CACNA1F O60840 1/20 0.79
AR P10275 1/20 0.79
PDE4A P27815 1/20 0.79
SCN1A P35498 1/20 0.79
SCN4A P35499 1/20 0.79
SCN7A Q01118 1/20 0.79
CACNA1D Q01668 1/20 0.79
CACNA1S Q13698 1/20 0.79
CACNA1C Q13936 1/20 0.79
SCN5A Q14524 1/20 0.79
SCN9A Q15858 1/20 0.79
SCN2A Q99250 1/20 0.79
SCN3A Q9NY46 1/20 0.79
SCN11A Q9UI33 1/20 0.79
SCN8A Q9UQD0 1/20 0.79
SCN10A Q9Y5Y9 1/20 0.79
LMNA P02545 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cifenline SCHEMBL122806 0.89 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL23712302 0.89 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL23712274 0.89 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL121044 0.87 CACNA1F (0.79) CACNA1FARPDE4ASCN1ASCN4A
Fumaric Acid SCHEMBL10760662 0.68 NISCH (0.52) LMNASMN1; SMN2RAB9AADRA2AADRA2B
Fumaric Acid SCHEMBL9868088 0.65 LMNA (0.43) LMNASMN1; SMN2RAB9A
Maleic Acid SCHEMBL9868080 0.65 LMNA (0.43) LMNASMN1; SMN2RAB9A
SCHEMBL10467674 0.64 LMNA (0.41) LMNAMAOB
SCHEMBL10467989 0.64 LMNA (0.41) LMNAMAOB
SCHEMBL10467987 0.64 LMNA (0.41) LMNAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230248734-A1 ANTIVIRAL COMPOSITION OBTAINED THROUGH DRUG REPOSITIONING KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2023-08-10 US claimed
US-12533343-B2 Method for preparing (−)-cibenzoline succinate CELLTRION, INC. (KR) 2026-01-27 US disclosed
US-12533343-B2 Method for preparing (−)-cibenzoline succinate CELLTRION, INC. (KR) 2026-01-27 US disclosed
US-12486237-B2 Polymorphic form of (-)-cibenzoline succinate CELLTRION INC. (KR) 2025-12-02 US disclosed
US-20240366627-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2024-11-07 US disclosed
US-11963964-B2 Small molecules for mouse satellite cell proliferation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-04-23 US disclosed
US-20230248734-A1 ANTIVIRAL COMPOSITION OBTAINED THROUGH DRUG REPOSITIONING KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2023-08-10 US disclosed
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE CELLTRION, INC. (KR) 2023-04-20 US disclosed
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE CELLTRION, INC. (KR) 2023-04-20 US disclosed
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE CELLTRION, INC. (KR) 2023-04-20 US disclosed
US-20230088511-A1 Polymorphic Form of (-)-Cibenzoline Succinate CELLTRION INC. (KR) 2023-03-23 US disclosed
US-20230088511-A1 Polymorphic Form of (-)-Cibenzoline Succinate CELLTRION INC. (KR) 2023-03-23 US disclosed
US-20230040902-A1 Pharmaceutical Formulation Comprising Cibenzoline or Salt Thereof CELLTRION INC. (KR) 2023-02-09 US disclosed
US-11426400-B2 Methods of increasing satellite cell proliferation with vorinostat or bosutinib PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-08-30 US disclosed
EP-3858816-A4 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE Celltrion, Inc. (KR) 2022-06-15 EP disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 KCNH2 4204/4885CACNA1F 2950/4885AR 3548/4885
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE SDHA, SDHB, ALDH5A1 KCNH2 1902/4885CACNA1F 386/4885AR 1072/4885
US-20230088511-A1 Polymorphic Form of (-)-Cibenzoline Succinate SDHA, SDHB, ALDH5A1 KCNH2 1975/4885CACNA1F 300/4885AR 2420/4885
US-20240366627-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 KCNH2 4204/4885CACNA1F 2950/4885AR 3548/4885
US-11963964-B2 Small molecules for mouse satellite cell proliferation MKI67, MYLK2, MYH2 KCNH2 4204/4885CACNA1F 2950/4885AR 3548/4885
US-20230248734-A1 ANTIVIRAL COMPOSITION OBTAINED THROUGH DRUG REPOSITIONING SARS1, EIF2AK2, ACE2 KCNH2 3255/4885CACNA1F 3929/4885AR 4779/4885
US-11426400-B2 Methods of increasing satellite cell proliferation with vorinostat or bosutinib MKI67, CDK4, CDKN1A KCNH2 4100/4885CACNA1F 3275/4885AR 2003/4885
US-20230040902-A1 Pharmaceutical Formulation Comprising Cibenzoline or Salt Thereof CEL, SLC6A12, SLC6A1 KCNH2 997/4885CACNA1F 130/4885AR 3876/4885
US-12486237-B2 Polymorphic form of (-)-cibenzoline succinate SDHA, SDHB, ALDH5A1 KCNH2 2029/4885CACNA1F 308/4885AR 2526/4885
US-12533343-B2 Method for preparing (−)-cibenzoline succinate CIP2A, CACNA1A, SDHA KCNH2 450/4885CACNA1F 32/4885AR 2897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.