Cifenline

Cifenline

SCHEMBL122806

c1ccc(C2(c3ccccc3)CC2C2=NCCN2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 1/20 1.00
AR P10275 1/20 1.00
PDE4A P27815 1/20 1.00
SCN1A P35498 1/20 1.00
SCN4A P35499 1/20 1.00
SCN7A Q01118 1/20 1.00
CACNA1D Q01668 1/20 1.00
KCNH2 Q12809 1/20 1.00
CACNA1S Q13698 1/20 1.00
CACNA1C Q13936 1/20 1.00
SCN5A Q14524 1/20 1.00
SCN9A Q15858 1/20 1.00
SCN2A Q99250 1/20 1.00
SCN3A Q9NY46 1/20 1.00
SCN11A Q9UI33 1/20 1.00
SCN8A Q9UQD0 1/20 1.00
SCN10A Q9Y5Y9 1/20 1.00
ADRA2A P08913 8/20 0.49
ADRA2B P18089 3/20 0.49
ADRA2C P18825 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cifenline SCHEMBL23712274 1.00 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL23712302 1.00 CACNA1F (1.00) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL121044 0.89 CACNA1F (0.79) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL29387230 0.89 CACNA1F (0.79) CACNA1FARPDE4ASCN1ASCN4A
Cifenline SCHEMBL28086532 0.74 CACNA1F (0.55) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL5998298 0.68 KDM1A (0.57) CACNA1FARPDE4ASCN1ASCN4A
Biphenyl SCHEMBL27968805 0.67 NISCH (0.58) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL23712311 0.67 CACNA1F (0.50) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL17886752 0.66 NISCH (1.00) CACNA1FARPDE4ASCN1ASCN4A
SCHEMBL17886835 0.66 NISCH (1.00) CACNA1FARPDE4ASCN1ASCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12551465-B2 Pharmaceutical composition for treatment of hypertrophic cardiomyopathy and treatment method using same composition CELLTRION INC. (KR) 2026-02-17 US claimed
US-12533343-B2 Method for preparing (−)-cibenzoline succinate CELLTRION, INC. (KR) 2026-01-27 US claimed
US-12419863-B2 Pharmaceutical composition for use in treatment of hypertrophic cardiomyopathy CELLTRION INC. (KR) 2025-09-23 US claimed
EP-3485876-B1 ORAL PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING PARTICULATE FORMULATION COMPRISING COMPOSITION SUNSHO PHARMACEUTICAL CO LTD (JP) 2023-11-22 EP claimed
US-20230190708-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION CELLTRION, INC. (KR) 2023-06-22 US claimed
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE CELLTRION, INC. (KR) 2023-04-20 US claimed
EP-4140482-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION Celltrion, Inc. (KR) 2023-03-01 EP claimed
US-20230040902-A1 Pharmaceutical Formulation Comprising Cibenzoline or Salt Thereof CELLTRION INC. (KR) 2023-02-09 US claimed
EP-4079297-A1 PHARMACEUTICAL FORMULATION COMPRISING CIBENZOLINE OR SALT THEREOF Celltrion, Inc. (KR) 2022-10-26 EP claimed
EP-3618813-B1 IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS LUBRIZOL ADVANCED MAT INC (US) 2022-07-06 EP claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-6645524-B2 Capsules housing compressed tablets or drug-containing beads, for administering isomers of solatol and other antiarrhythmics/adrenergic blocking agents PIERCE MANAGEMENT LLC 2003-11-11 US claimed
EP-1311247-A1 ORAL PHARMACEUTICAL DOSAGE FORMS FOR PULSATILE DELIVERY OF AN ANTIARRHYTHMIC AGENT Peirce Management, Llc (US) 2003-05-21 EP claimed
US-20020115655-A1 Such as S-(4-methoxybenzyl)-N-(2-(N',N'-dimethylamino)ethyl) thiosalicylamide; for treatment of cardiovascular disorders MASSACHUSETTS COLLEGE OF PHARMACY 2002-08-22 US claimed
US-20020098232-A1 Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent COLLEGIUM PHARMACEUTICAL, INC. 2002-07-25 US claimed
WO-2002013794-A1 ORAL PHARMACEUTICAL DOSAGE FORMS FOR PULSATILE DELIVERY OF AN ANTIARRHYTHMIC AGENT PEIRCE MANAGEMENT, LLC (US) 2002-02-21 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12419863-B2 Pharmaceutical composition for use in treatment of hypertrophic cardiomyopathy CPT1B, TNNT2, TNNC1 CACNA1F 233/4885AR 2149/4885PDE4A 2438/4885
US-12551465-B2 Pharmaceutical composition for treatment of hypertrophic cardiomyopathy and treatment method using same composition ME2, TNNT2, TNNC1 CACNA1F 292/4885AR 3630/4885PDE4A 3415/4885
US-20230122169-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE SDHA, SDHB, ALDH5A1 CACNA1F 386/4885AR 1072/4885PDE4A 1773/4885
US-20020115655-A1 Such as S-(4-methoxybenzyl)-N-(2-(N',N'-dimethylamino)ethyl) thiosalicylamide; for treatment of cardiovascular disorders CACNA1G, CACNA1F, CACNA1H CACNA1F 2/4885AR 3339/4885PDE4A 898/4885
US-20230040902-A1 Pharmaceutical Formulation Comprising Cibenzoline or Salt Thereof CEL, SLC6A12, SLC6A1 CACNA1F 130/4885AR 3876/4885PDE4A 574/4885
US-20230190708-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION ATP2A2, CPT1B, TNNT2 CACNA1F 159/4885AR 2850/4885PDE4A 2140/4885
US-12533343-B2 Method for preparing (−)-cibenzoline succinate CIP2A, CACNA1A, SDHA CACNA1F 32/4885AR 2897/4885PDE4A 1206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.