Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830380 | 0.84 | LMNA (0.40) | LMNAHSP90AB1PDE10AHTTSMN1; SMN2 | |
| SCHEMBL4330004 | 0.80 | HSP90AB1 (0.33) | LMNAHSP90AB1ADORA1ADORA2AADORA3 | |
| SCHEMBL259072 | 0.80 | PDE10A (0.52) | LMNAHSP90AB1PDE10AADORA1ADORA2A | |
| SCHEMBL16938750 | 0.80 | LMNA (0.32) | LMNAHSP90AB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6424033 | 0.79 | HSP90AB1 (0.36) | LMNAHSP90AB1ADORA1ADORA2AADORA3 | |
| SCHEMBL10049719 | 0.79 | LMNA (0.39) | LMNAHSP90AB1PDE10AADORA2AALDH1A1 | |
| SCHEMBL16094459 | 0.76 | ADORA1 (0.39) | LMNAHSP90AB1ADORA1ADORA2AADORA3 | |
| SCHEMBL7522506 | 0.76 | LMNA (0.38) | LMNAPDE10ANOS3NOS2ALDH1A1 | |
| SCHEMBL2371941 | 0.76 | MAP2K7 (0.30) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL5561175 | 0.76 | ALDH1A1 (0.31) | HSP90AB1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587112-B | Rho-related inhibitors of coiled-coil-containing protein kinases | 卡德门企业有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2023-03-28 | — | — | US | disclosed |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC | 2020-06-25 | — | — | US | disclosed |
| US-20130096104-A1 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |
| US-20070197523-A1 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| WO-2004034967-A2 | 2,4,6-TRIAMINOPYRIMIDINES FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096104-A1 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TYK2, IRAK1, IRAK4 | LMNA 2401/4885HSP90AB1 2317/4885PDE10A 4101/4885 |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | LMNA 2071/4885HSP90AB1 327/4885PDE10A 1234/4885 |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | LMNA 2071/4885HSP90AB1 327/4885PDE10A 1234/4885 |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | LMNA 2071/4885HSP90AB1 327/4885PDE10A 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.