Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | SCD | O00767 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23357 | 0.82 | RAB9A (0.84) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22880 | 0.80 | DYRK1A (0.67) | DYRK1A | |
| SCHEMBL31065 | 0.78 | SCD (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| Frentizole SCHEMBL599582 | 0.78 | RAB9A (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| Frentizole SCHEMBL11433152 | 0.77 | RAB9A (0.98) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4918595 | 0.77 | NPC1 (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1282877 | 0.77 | ABL1 (0.83) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2733651 | 0.77 | RAB9A (0.70) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11724051 | 0.77 | RAB9A (0.74) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4922394 | 0.77 | ATAD2 (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |