Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 14/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23715998 | 0.79 | S1PR3 (0.42) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL23715847 | 0.75 | S1PR3 (0.42) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL23716102 | 0.75 | S1PR3 (0.40) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL17663930 | 0.68 | S1PR3 (0.47) | S1PR3S1PR4S1PR2S1PR1MEN1 | |
| SCHEMBL23715931 | 0.67 | S1PR3 (0.44) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL17664015 | 0.65 | S1PR3 (0.66) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL17663900 | 0.64 | S1PR3 (0.60) | S1PR3S1PR4S1PR1S1PR5 | |
| SCHEMBL23716138 | 0.63 | LMNA (0.34) | S1PR3S1PR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13153641 | 0.60 | S1PR3 (0.54) | S1PR3S1PR4S1PR2S1PR1S1PR5 | |
| SCHEMBL28736369 | 0.59 | LMNA (0.55) | S1PR3S1PR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |