SCHEMBL23715914

SCHEMBL23715914

Cc1ccc(Cc2cc3ccccc3cn2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.48
CYP2A6 P11509 2/20 0.48
PDE10A Q9Y233 4/20 0.45
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PDPK1 O15530 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
HTR2B P41595 1/20 0.39
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
HTR3A P46098 1/20 0.38
LMNA P02545 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37
HTT P42858 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21363719 0.86 CYP2A6 (0.50) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL3121339 0.85 HTR2B (0.50) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL3119876 0.83 CYP1A2 (0.46) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL3116975 0.83 NPC1 (0.55) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL17664092 0.83 HSP90AB1 (0.47) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL6982798 0.79 L3MBTL1 (0.41) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL21951174 0.77 CYP1A2 (0.44) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL3128182 0.77 PDE10A (0.52) CYP1A2CYP2A6PDE10AATML3MBTL1
SCHEMBL3129580 0.77 SLC6A2 (0.44) PDE10AATML3MBTL1TDP1ALDH1A1
SCHEMBL21031190 0.76 PDE10A (0.52) CYP1A2CYP2A6PDE10AATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3209732-B1 SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS SCRIPPS RESEARCH INST (US) 2021-08-04 EP disclosed