Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17664039 | 0.87 | RAPGEF4 (0.40) | RAPGEF4P2RX7PARP1KCNH2FPR2 | |
| SCHEMBL17664049 | 0.87 | PARP1 (0.35) | RAPGEF4P2RX7PARP1KCNH2FPR2 | |
| SCHEMBL17664035 | 0.84 | S1PR1 (0.38) | RAPGEF4P2RX7PARP1KCNH2FPR2 | |
| SCHEMBL23716252 | 0.79 | RAPGEF4 (0.35) | RAPGEF4P2RX7PARP1KCNH2FPR2 | |
| SCHEMBL17664085 | 0.76 | PARP1 (0.37) | PARP1GRM2QPCTQPCTLGPR52 | |
| SCHEMBL23716095 | 0.75 | GPR52 (0.34) | ANO1KDM5AKDM5BGRM2AKT1 | |
| SCHEMBL17664040 | 0.71 | NPC1 (0.37) | RAPGEF4KCNH2CYP2C19GPR52 | |
| SCHEMBL17664034 | 0.71 | TSHR (0.42) | KCNH2MAPK1 | |
| SCHEMBL21384047 | 0.70 | CYP3A4 (0.42) | GRM2QPCTCYP3A4QPCTLGPR52 | |
| SCHEMBL17664392 | 0.70 | PARP1 (0.45) | P2RX7PARP1ANO1KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |