SCHEMBL23716095

SCHEMBL23716095

Bc1ccc(Cc2ccc(Cl)c(F)c2)nc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 1/20 0.34
FYN P06241 1/20 0.34
GRM2 Q14416 1/20 0.33
MAPK1 P28482 2/20 0.33
MAPT P10636 1/20 0.33
KCNQ3 O43525 2/20 0.32
KCNQ2 O43526 2/20 0.32
KCNE1 P15382 2/20 0.32
KCNQ1 P51787 2/20 0.32
KCNQ5 Q9NR82 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
DRD4 P21917 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
ANO1 Q5XXA6 1/20 0.31
KDM5A P29375 1/20 0.31
KDM5B Q9UGL1 1/20 0.31
AKT1 P31749 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23716355 0.87 PNMT (0.42) MAPK1
SCHEMBL17664001 0.86 GPR52 (0.35) GPR52FYNGRM2MAPK1MAPT
SCHEMBL17664118 0.83 GBA1 (0.44) GPR52GRM2MAPK1MAPT
SCHEMBL17664040 0.83 NPC1 (0.37) GPR52KCNQ3KCNQ2KCNE1KCNQ1
SCHEMBL17663898 0.79 KCNQ3 (0.37) GPR52GRM2MAPK1MAPTKCNQ3
SCHEMBL23716077 0.78 HSP90AB1 (0.42) MAPK1HDAC3HDAC1HDAC2HDAC6
SCHEMBL17664090 0.76 NPC1 (0.40) GRM2DRD4SIGMAR1PPARGPPARA
SCHEMBL17664100 0.76 FYN (0.41) FYNKDM5AKDM5B
SCHEMBL23715992 0.75 RAPGEF4 (0.33) GPR52GRM2MAPK1MAPTANO1
SCHEMBL17664358 0.74 HDAC3 (0.41) GPR52HDAC3HDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3209732-B1 SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS SCRIPPS RESEARCH INST (US) 2021-08-04 EP disclosed