Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23716095 | 0.87 | GPR52 (0.34) | MAPK1 | |
| SCHEMBL17663857 | 0.83 | IDO1 (0.42) | PNMTIDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23716077 | 0.81 | HSP90AB1 (0.42) | IDO1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL17664391 | 0.80 | PNMT (0.42) | PNMTIDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17664101 | 0.80 | GBA1 (0.53) | PNMTIDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17664076 | 0.76 | IDO1 (0.42) | PNMTIDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3129580 | 0.72 | SLC6A2 (0.44) | IDO1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL17664001 | 0.72 | GPR52 (0.35) | IDO1SLC6A4MAPK1 | |
| SCHEMBL3298586 | 0.71 | IDO1 (0.64) | PNMTIDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21383993 | 0.70 | ALDH1A1 (0.59) | PNMTIDO1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |