SCHEMBL23716368

SCHEMBL23716368

Cc1ccc(Cc2ccc(C#N)cc2)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.48
ALDH1A1 P00352 1/20 0.48
LOXL2 Q9Y4K0 2/20 0.46
HRH3 Q9Y5N1 1/20 0.44
CYP11B1 P15538 2/20 0.43
CYP11B2 P19099 2/20 0.43
CYP19A1 P11511 2/20 0.42
IDH1 O75874 1/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
BCHE P06276 1/20 0.40
ACHE P22303 1/20 0.40
MBOAT4 Q96T53 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
AR P10275 1/20 0.39
ALOX5AP P20292 1/20 0.38
SAE1 Q9UBE0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18622091 0.84 KEAP1 (0.50) CYP2A6ALDH1A1KEAP1NFE2L2ACHE
SCHEMBL17664102 0.80 MAOA (0.45) CYP2A6ALDH1A1LOXL2HRH3CYP11B1
SCHEMBL13401234 0.79 KEAP1 (0.44) HRH3KEAP1NFE2L2CYP1A2
SCHEMBL14346503 0.78 CYP2A6 (0.73) CYP2A6ALDH1A1LOXL2HRH3CYP11B1
SCHEMBL23742239 0.78 LOXL2 (0.43) CYP2A6ALDH1A1LOXL2HRH3MBOAT4
SCHEMBL5652510 0.77 ESR1 (0.46) ALDH1A1IDH1KEAP1NFE2L2ACHE
SCHEMBL13401245 0.77 KEAP1 (0.43) HRH3KEAP1NFE2L2CYP1A2
SCHEMBL17664027 0.77 KEAP1 (0.43) ALDH1A1KEAP1NFE2L2
SCHEMBL13562421 0.77 ALDH1A1 (0.46) ALDH1A1KEAP1NFE2L2CYP3A4CYP2C19
SCHEMBL17663986 0.77 SMO (0.46) LOXL2HRH3CYP19A1MBOAT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3209732-B1 SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS SCRIPPS RESEARCH INST (US) 2021-08-04 EP disclosed