SCHEMBL23716871

SCHEMBL23716871

O=C1C=CC(=O)N1[CH]CN1C(=O)C=CC1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 12/20 0.44
FAAH O00519 5/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 2/20 0.44
MAPT P10636 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
BLM P54132 2/20 0.44
GMNN O75496 1/20 0.44
THPO P40225 1/20 0.44
PMP22 Q01453 1/20 0.44
HPGD P15428 2/20 0.42
HSP90AA1 P07900 1/20 0.42
TLR9 Q9NR96 1/20 0.42
TP53 P04637 1/20 0.42
PKM P14618 1/20 0.42
XBP1 P17861 1/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
RECQL P46063 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15577150 0.76 MGLL (0.38) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL20528097 0.72 MGLL (0.46) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL88581 0.72 CASP3 (0.48) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL2496082 0.68 MGLL (0.42) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL6537077 0.68 MGLL (0.48) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL1955696 0.68 MGLL (0.42) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL4989707 0.67 MGLL (0.46) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL28572221 0.66 MGLL (0.42) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL114195 0.66 MGLL (0.58) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL756295 0.64 AKR1B1 (0.43) MGLLFAAHALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310624-A1 AFFIBODY-CYTOTOXIN CONJUGATE FOR ACTIVE TARGETED THERAPY OF TUMORS, NANOPARTICLE THEREOF, PREPARATION METHOD THEREOF AND APPLICATION THEREOF SHANGHAI JIAOTONG UNIVERSITY (CN) 2023-10-05 US disclosed
EP-4230224-A1 AFFIBODY-CYTOTOXIN CONJUGATE USED FOR ACTIVE TUMOR TARGETING THERAPY, AND NANOPARTICLES, PREPARATION METHOD, AND APPLICATION THEREOF SHANGHAI JIAOTONG UNIVERSITY (CN) 2023-08-23 EP disclosed
CN-112220931-B Affinity body-cytotoxin conjugate for active targeted therapy of tumor, nanoparticle thereof, preparation method and application 上海交通大学 2022-03-08 CN disclosed
EP-3862389-B1 CHLOROPRENE RUBBER COMPOSITION AND VULCANIZATION MOLDED BODY DENKA COMPANY LTD (JP) 2022-02-23 EP disclosed
US-20220002526-A1 CHLOROPRENE RUBBER COMPOSITION AND VULCANIZATION MOLDED BODY DENKA COMPANY LIMITED (JP) 2022-01-06 US disclosed
EP-3862389-A1 CHLOROPRENE RUBBER COMPOSITION AND VULCANIZATION MOLDED BODY Denka Company Limited (JP) 2021-08-11 EP disclosed
CN-112220931-A Affinity body-cytotoxin conjugate for active targeted therapy of tumor, nanoparticle thereof, preparation method and application 上海交通大学 2021-01-15 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230310624-A1 AFFIBODY-CYTOTOXIN CONJUGATE FOR ACTIVE TARGETED THERAPY OF TUMORS, NANOPARTICLE THEREOF, PREPARATION METHOD THEREOF AND APPLICATION THEREOF ASGR1, FCGR2A, FCGR1A MGLL 4538/4885FAAH 885/4885ALDH1A1 2131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.